Medical Research Projects Etiology of chronic infections in patients with chronic bronchial obstructive diseases

Etiology of chronic infections in patients with chronic bronchial obstructive diseases

  • Project :
    • Etiology of chronic infections in patients with chronic bronchial obstructive diseases
  • Project director :
    • Prof. Dr. Emanoil Ceausu
  • Coordinating institution :
    • Spitalul Clinic de Boli Infectioase si Tropicale "Dr. Victor Babes" Bucuresti
    • Executive : Dr. Maria Zlatev Ionescu
  • Partners :
    • P1 - Fundatia "Dr. Victor Babes" Bucuresti
      • Executive P1: Dr. Iuliana Apostol
    • P2 - Spitalul de Pneumologie "Sf. Stefan" Bucuresti
      • Executive P2 : Dr. Daniela Chirita
  • Period :
    • 2007 - 2010
  • Funding :
    • Ministerul Educatiei si Cercetarii - Centrul National de Management Programe - PN II 41-086/2007
  • About the project :
    • The ongoing bronchopulmonary inflammatory process in chronic respiratory infections has a deletory effect on the quality of life of the patients through the recurrent exacerbations and the rapid decline of the respiratory function.
      In this study we want to establish, on a sufficient number of patients with chronic respiratory infections, the bacterial etiology, the sensitivity to antibiotics and we want to measure the impact of efficient antibiotic treatment and immunomodulators (azithromycin for 6 months) to patients with chronic respiratory infections without cystic fibrosis or active tuberculosis. It is the first study designed toward this endpoint and with this magnitude in Romania.
    • Primary outcomes :
      • etiology of acute exacerbations of chronic infections of bronhoobstructive patients; etiology of chronic infections in the periods between exacerbations; modifications of the bronchial aspirate with azithromycin treatment
      • the reduction of the number of infectious exacerbations in at least 6 months of azithromycin treatment; establishing of the number of days until the first exacerbation after the beginning of long term treatment with azithromycin.
    • Secondary outcomes :
      • number of occurrences of acute exacerbations
      • emergency department visits as a result of acute exacerbations and number of hospital admissions as a result of acute exacerbations number of hospital days as a result of acute exacerbations
      • incidence of presumed macrolide-related side-effects and incidence of presumed macrolide-related side effects that require cessation of treatment
      • incidence of macrolide resistant bacteria
      • quality of life
      • decline of respiratory function in the presence of long term treatment with azithromycin
      • cost-effectiveness (all measured over a 6-month period).
  • Events
    • "Controversies in infectious pathology" - National Conference of Infectious Diseases, 27 - 29 November 2008, Iasi, Romania
    • "13th Scientific Meeting of the European Society of Chemotherapy/Infectious Diseases", 3 - 6 December 2008, Vienne, Austria
    • "19th European Congress of Clinical Microbiology an Infectious Diseases-ECCMID", 16 - 19 May 2009, Helsinki, Finland